Volume 2, Number 3 (9-2011)                   jdc 2011, 2(3): 137-142 | Back to browse issues page


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Herizchi Qadim H, Babaei Nejad S, Golfroushan F, Azimi H, Azadi A. Comparison of the efficacy of 0.05% tretinoin with 7% alpha-hydroxy acid cream in the treatment of ephelides: A controlled clinical trial. jdc. 2011; 2 (3) :137-142
URL: http://jdc.tums.ac.ir/article-1-19-en.html

Abstract:   (10262 Views)

Background and Aim: Anti-inflammatory and hypo- pigmenting effects of topical tretinoin and alpha-hydroxy acids have been documented. This study was designed to compare the efficacy of 0.05% tretinion cream with 7% alpha-hydroxy acid in the treatment of ephelides.
Methods: In this clinical trial 80 patients with ephelides were selected and allocated into two groups. One group was treated with 0.05% tretinoin cream every other night. The other group was treated with 7% alpha-hydroxy acid cream in the same manner. Both groups were treated with antisolar creams and followed every month for 5 months.
Results: After 5 months excellent therapeutic response was achieved in 3 (7.5%) of patients who were treated with 0.05% tretinoin cream compared to 8 (20%) in alpha-hydroxy acid cream. Good therapeutic response was observed in 20 (50%) of tretinoin group versus 16 (40%) in alpha-hydroxy acid group. Patient's satisfaction from treatment was consistent with evaluation by dermatologists (P=0.384 and P=0.132).
Conclusion: Both 0.05% tretinoin cream and 7% alpha-hydroxy acid cream are equally efficient in the treatment of ephelides.

Full-Text [PDF 267 kb]   (1672 Downloads)    
Type of Study: Research | Subject: General
Received: 2011/10/13 | Accepted: 2011/11/20 | Published: 2013/07/16

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