Volume 4, Number 1 (3-2013)                   jdc 2013, 4(1): 27-33 | Back to browse issues page


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Naderi M, Shamshiri H, Alizadeh S, Dorgalaleh A, Manafi R, Tabibian S. Cutaneous and mucosal manifestations in patients with beta major thalassemia . jdc. 2013; 4 (1) :27-33
URL: http://jdc.tums.ac.ir/article-1-5024-en.html

1- Zahedan University of Medical Sciences, Zahedan, Iran.
2- Zahedan University of Medical Sciences, Zahedan, Iran. , naderidactorxiii@yahoo.com
3- Tehran University of Medical Sciences, Tehran, Iran.
Abstract:   (6372 Views)
Background and Aim: Thalassemia is one of the most common single gene disorder that results from decrease or absence of globulin chain(s) synthesis. Repeated blood transfusion is required for prevention of severe anemia and related side effects, but it is associated with other complications such as cutaneous lesions and mucosal manifestations. This study conducted to assess the frequency of cutaneous and mucosal manifestations in patients with beta thalassemia.
Methods: This cross-sectional study was conducted on 300 patients with beta major thalassemia in Zahedan. Data were obtained from medical records and questionnaires as well as through physical examination of patients. The data were statistically described and tested.
Results: The mean age of patients was 17.9±6.3 years and 64.3% of patients were men and 35.7% were women. Among cutaneous lesions, freckles were the most common (70.7%) and the rarest one was peri orbital pigmentation (0.3%). Gingivitis (41.7%) and longitudinal lines on nails (72%) were the most common mucosal and nail manifestations.
Conclusion: Since cutaneous and mucosal manifestations are very common among patients with beta major thalassemia, regular dermatology follow up of these patients is recommended.
Full-Text [PDF 352 kb]   (1542 Downloads)    
Type of Study: Research | Subject: General
Received: 2013/02/11 | Accepted: 2013/03/14 | Published: 2013/07/16

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