Volume 7, Number 1 (Volume 7, Number 1 2016)                   jdc 2016, 7(1): 1-9 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shamsi Meymandi S, Mohammadzadeh Shanehsaz S, Ansari Dogaheh M, jahani Y. Efficacy of licorice extract in the treatment of melasma: A randomized, double-blind, placebo-controlled clinical trial. jdc. 2016; 7 (1) :1-9
URL: http://jdc.tums.ac.ir/article-1-5170-en.html

1- Dermatology and Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran - Depatment of Dermatology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
2- Dermatology and Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran - Depatment of Dermatology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran , mdsiavash@yahoo.com
3- Pharmaceutics Research Center, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
4- Department of Biostatistics and Epidemiology, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran
Abstract:   (3316 Views)

Background and Aim: Melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. The goal of this study was to evaluate the efficacy of a cream containing 4% licorice extract with a novel formulation based on solid lipid nanoparticles technology in the treatment of melasma. To the best of our knowledge, it is the first study designed to investigate the efficacy of this novel formulation in the treatment of melasma all over the world.

Methods: In this randomized, double-blind, placebo-controlled clinical trial, 44 women with clinical diagnosis of melasma referred to the Afzalipour hospital dermatology clinic were randomly allocated into two treatment groups of equal size. All the patients were interviewed and examined every four weeks during the trial and their Modified Melasma Area and Severity Index (MMASI) score were evaluated at 4, 8 and 12 weeks. The efficacy of the interventions were classified in four levels: complete response, significant response, partial response and no response.

Results: Forty patients were enrolled in the study. At the end of the study (12 weeks), mean± standard deviation of MMASI score changed from 11.03±2.7 to 1.41±0.6 in the intervention group and from 11.25±2.9 to 2.37±1.2 in the placebo group, respectively (P<0.001).

Conclusion: Licorice extract can be used as a skin-lightening agent with minimal side effect in the treatment of melasma. Nano/micro solid lipid particles are used as carriers with unique properties like size, surface electrical bar. Moreover, a large amount of the drug might be loaded to increase the efficacy and decrease the adverse events.

Full-Text [PDF 306 kb]   (1319 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/06/19 | Accepted: 2016/06/19 | Published: 2016/06/19

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2017 All Rights Reserved | Journal of Dermatology and Cosmetic

Designed & Developed by : Yektaweb