Volume 7, Number 1 (Volume 7, Number 1 2016)                   jdc 2016, 7(1): 10-16 | Back to browse issues page


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Taheri A R, Khorasani G A, Forghani S, Fathi A. Treatment of hypertrophic scar with intralesional injection of botulinum toxin A: A double-blind, randomized controlled clinical trial. jdc. 2016; 7 (1) :10-16
URL: http://jdc.tums.ac.ir/article-1-5171-en.html

1- Department of Plastic and Reconstructive Surgery, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , taheriah@sina.tums.ac.ir
2- Department of Plastic and Reconstructive Surgery, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Plastic and Reconstructive Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (2455 Views)

Background and Aim: Hypertrophic scars are highly resistant to the treatment and have a high recurrence rate. Affected patients suffer from aesthetic and functional complications, which may influence their quality of life. Nowadays, various therapeutic modalities have been used in the treatment of hypertrophic scars, but patients' problems remain because of high recurrence rate. This study evaluated the efficacy of intralesional injection of botulinum toxin A in the treatment of hypertrophic scar lesions.

Methods: This randomised controlled trial was performed during 2014 and 2015. Each patient`s lesion was randomly allocated in ine of the two arms of the study: one half of the lesion received monthly 8 IU/cm3 of 200 IU/ml intralesional botulinum toxin A (Dysport, Ipsen Biopharma Ltd., UK) and the other half was injected with the same volume of normal saline. Injections were repeated three times. After 9 months, lesions were evaluated according to Vancouver scar scale.

Results: Twenty-one patients with a mean age of 27.2 years completed the study. In the intervention the mean lesions` pigmentation scale decrease to 0.73, vascularity to 0.9 and pliability to 0.98 (P<0.01), but there was no significant change in lesions height (P=0.32).

Conclusion: It seems that injection of botulinum toxin A in hypertrophic scar lesions acts as useful adjuvant for other treatment methods.

Full-Text [PDF 333 kb]   (799 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/06/19 | Accepted: 2016/06/19 | Published: 2016/06/19

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