Volume 8, Issue 2 (Volume 8, Number 2 2017)                   jdc 2017, 8(2): 83-89 | Back to browse issues page

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Akbari K, Hashemian F, Shie morteza M, Toosi P. Incidence of side effects of nonbiologic systemic drugs used in management of psoriasis in patients referring to Dermatology Departments of Shohaday-e-Tajrish and Loghman-e-Hakim Hospitals from May 2016 to May 2017. jdc. 2017; 8 (2) :83-89
URL: http://jdc.tums.ac.ir/article-1-5253-en.html
1- Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
2- Department of Clinical Pharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
3- Department of Clinical Pharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran. , Mshi1973@yahoo.com
4- Department of Dermatology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:   (2690 Views)

Background and Aim: Psoriasis vulgaris is a chronic skin disease which is treated by many systemic or topical drugs. There is no cure for this disease and patients have to take medicaments for a long time, so having knowledge on adverse effects of current medicaments may prevent them and improve treatment process. The aim of this study was to evaluate the incidence of side effects of non biologic systemic drugs in psoriasis.

Methods: In this observational study, we evaluated 200 hospital charts of patients with moderate to-severe psoriasis referred to dermatology clinics of Shohada and Loghman Hospitals in Tehran in 2016. SPSS statistical tools were used to determine the percentage of adverse events. Chi square was used to show the association of gender-related complications and student T-test to evaluate age-related complications.

Results: %56 of patients were male, %26.5 were 25-34 year-old, with mean age of 42±14.2 years and %83.5 of patients had no family history of psoriasis. 11% of patients were hypertensive. Methotrexate was the most commonly used drug and the most common reported adverse event for it was increasing liver function tests (%6.2 in oral and %21.2 in IM injections). The most common reported adverse event for cyclosporine was increased blood pressure which was seen in 17 patients (15.3%). The most common side effect of acitertin was scaling, observed in 11 (%9.6) of patients. There was no relationship between age and sex of patients and development of side effects.

Conclusion: This study showed systemic treatments for psoriasis can change laboratory biomarkers and cause skin eruptions.

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Type of Study: Research | Subject: Special
Received: 2017/10/25 | Accepted: 2017/10/25 | Published: 2017/10/25

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