Journal of

Background and Aim: The standard treatment regimen for pemphigus is adminitration of systemic corticosteroids and adjuvant agents. Previous studies have shown that corticosteroid therapy may alter lipid profile and reduce the atherogenic index in some disorders. This study was conducted to evaluate the changes in lipid profile in pemphigus patients treated with oral corticosteroids alone or in combination with adjuvants.

Methods: In this retrospective corss-sectional study, medical records of 148 pemphigus patients admitted in Razi Hospital in Tehran were reviewed for serum levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholestrol, and triglyceride on the day of admission till 3 weeks after initiation of the treatment.

Results: Fifty-eight percent of patients were female and the mean age of the patients was 47.1 years. 79.3% and 13.3% of patients had been treated with prednisolone plus azathiorine or prednisolone alone, respectively. The remainig patients were treated by administration of oral prednisolone and other adjuvants. Serum levels of LDL, HDL, total cholestrol and triglyceride were significantly higher 3 weeks after initiation of treatment compared to baseline (P<0.05). With the exception of the signifcantly higher level of triglycerides in women, there was no statistically significant association between the levels of other serum lipids at the end of 3 weeks treatment with gender, age, severity of the disease, use of statins, and the treatment regimen (P>0.05).

Conclusion: Although the level of different components of the lipid profile in Iranian patients with pemphigus changed after receiving treatment for 3 weeks, it seems that those changes were not associated with an increased atherogenic index of pemphigus patients.