Volume 16, Issue 3 (Volume 16, No 3 2025)
jdc 2025, 16(3): 169-180 |
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Bakhtiyari H, Emaminia M, Bakhtiyari A. Epigenetics in the service of aesthetics: a review of novel skin rejuvenation strategies based on epigenetic modifications. jdc 2025; 16 (3) :169-180
URL: http://jdc.tums.ac.ir/article-1-5810-en.html
URL: http://jdc.tums.ac.ir/article-1-5810-en.html
1- Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran
2- Department of Genetics, Islamic Azad University, Ilam Branch, Ilma, Iran ,aminbkht@gmail.com
2- Department of Genetics, Islamic Azad University, Ilam Branch, Ilma, Iran ,
Abstract: (413 Views)
Skin aging is a complex process characterized by structural alterations, reduced elasticity, and wrinkle formation, adversely affecting self-confidence and quality of life. Emerging evidence indicates that epigenetic mechanisms—including DNA methylation, histone modifications, and microRNA regulation-play pivotal roles in initiating and progressing these changes. These modifications, which occur without altering the DNA sequence, are reversible and thus represent promising targets for rejuvenation interventions. This review provides a comprehensive analysis of the role of these pathways in skin aging, as well as the impact of environmental factors such as ultraviolet (UV) radiation, air pollution, and nutrition. Furthermore, it discusses innovative therapeutic strategies, including Sirtuin activators, histone modification inhibitors, platelet-rich plasma (PRP), cell-based therapies, and epigenetic editing technologies. Although preliminary results are encouraging, limitations such as the paucity of longitudinal studies, methodological heterogeneity, and safety and ethical concerns remain. Overall, a deeper understanding of epigenetics may open new avenues for personalized and non-invasive skin rejuvenation therapies.
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