Volume 16, Issue 3 (Volume 16, No 3 2025)
jdc 2025, 16(3): 212-214 |
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Fattahi M. Itraconazole-resistant tinea capitis caused by Microsporum canis in a child with Chronic Granulomatous Disease:
a case report. jdc 2025; 16 (3) :212-214
URL: http://jdc.tums.ac.ir/article-1-5813-en.html
URL: http://jdc.tums.ac.ir/article-1-5813-en.html
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran , dr.mahsafattahi@gmail.com
Abstract: (633 Views)
Background: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by defects in the NADPH oxidase complex, predisposing patients to severe bacterial and fungal infections. Dermatophytosis with severe inflammatory presentations such as tinea capitis is uncommon but challenging to manage in these patients.
Case presentation: We report a 9-year-old Iranian girl with autosomal recessive CGD who presented with refractory inflammatory scalp lesions. Mycological examination confirmed tinea capitis caused by Microsporum canis. Antifungal susceptibility testing showed reduced susceptibility to itraconazole, while susceptibility to terbinafine and fluconazole was preserved. Due to limited access to terbinafine, the patient received alternative management including antibacterial and anti-tuberculosis therapy, leading to clinical improvement.Conclusion: This case highlights the diagnostic and therapeutic challenges of dermatophytosis in CGD patients and emphasizes the importance of accurate mycological diagnosis, antifungal susceptibility testing, and individualized multidisciplinary management, particularly in resource-limited settings.
Keywords: chronic granulomatous disease, tinea capitis, microsporum canis, dermatophytosis, immunodeficiency
Type of Study: case report |
Subject:
General
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