Dermatology and Cosmetic
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شیوع درماتیک آتوپیک در بیماران مبتلا به آکنه
Prevalence of atopic dermatitis in patients with acne vulgaris
تخصصي
Special
پژوهشي
Research
<span style="font-family:B Mitra;"><span style="font-size:11.0pt;">زمینه و هدف:</span></span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"> درماتیت</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">آتوپیک</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">یک</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">بیماری</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مزمن</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">التهابی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">است. این</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">بیماری درنتیجه یک فرآیند</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">التهابی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">تحریکشده</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">توسط</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">سلولهای </span></span><span dir="LTR">Th 2</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"> فعالشده</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مواجهه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">با</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">آلرژنها</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">ایجاد میشود. آکنه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">وولگاریس</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">یک</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">بیماری</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">التهابی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مزمن</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">پوستی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">است. مطالعات</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">اخیر</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">نشان میدهند</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">که</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">پروپیونی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">باکتریوم</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">آکنه باعث</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">القای</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">تولید </span></span><span dir="LTR">IL-17</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"> توسط</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">سلولهای</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مونونوکلئار محیطی و سلولهای </span></span><span dir="LTR">T</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"> (</span></span><span dir="LTR">Th1/Th17</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">) میشود.</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مطالعه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">حاضر</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">جهت</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">بررسی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">شیوع</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">درماتیت آتوپیک</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">بیماران</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مبتلا</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">به</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">آکنه طراحی شده است.</span></span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"></span></span><br>
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<span style="font-family:B Mitra;"><span style="font-size:11.0pt;">روش اجرا: </span></span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">این</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مطالعه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">موردی ـ شاهدی،</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">گروه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مورد</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">شامل</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">75</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">فرد</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مبتلا</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">به</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">آکنه و</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">گروه کنترل</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">شامل</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">75</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">فرد</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">با</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">عدم</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">ابتلا</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">به</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">آکنه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">که</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">ازنظر</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">سن</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">جنس</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">همانندسازی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">شدهاند</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مورد مطالعه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">قرار</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">گرفتند. در</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">هر</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">دو</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">گروه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">به</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">روش</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مصاحبه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">علائم</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">درماتیت</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">آتوپیک، آسم</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">رینیت آلرژیک</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">را</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">زمان</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">حال</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">گذشته</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">بررسی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">کردیم.</span></span><br>
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<span style="font-family:B Mitra;"><span style="font-size:11.0pt;">یافتهها:</span></span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"> احتمال</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">وجود</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">درماتیت</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">آتوپیک</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">زمان</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">حال</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">افرادی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">که آکنه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">داشتند</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">کمتر</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">از</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">افرادی بود</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">که</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">آکنه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">نداشتند. تفاوت</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">معنیداری</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">بین</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">گروه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مورد</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و شاهد</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">در فراوانی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">سابقه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">درماتیت آتوپیک در گذشته،</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">فراوانی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">آسم و</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">رینیت</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">آلرژیک</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">زمان</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">حال</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">گذشته وجود نداشت.</span></span><br>
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<span dir="RTL"><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">نتیجهگیری:</span></span></span><span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;"> وجود</span></span></span> <span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;">رابطه</span></span></span> <span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;">بین</span></span></span> <span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;">آکنه</span></span></span> <span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;">با</span></span></span> <span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;">متغیر</span></span></span> <span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;">درماتیت</span></span></span> <span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;">آتوپیک</span></span></span> <span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;">در</span></span></span> <span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;">زمان</span></span></span> <span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;">حال میتواند مؤید این مطلب باشد که فعالیت </span></span></span><span style="font-family:Times New Roman;"><span style="font-size:11.0pt;">Th2</span></span><span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;"> میتواند باعث کاهش شیوع بیماریهایی با فعالیت </span></span></span><span style="font-family:Times New Roman;"><span style="font-size:11.0pt;">Th1</span></span><span dir="RTL"><span style="font-family:B Nazanin;"><span style="font-size:13.0pt;"> شود. با این حال باید مطالعات بیشتری برای تأیید آن صورت گیرد.</span></span></span>
<p>Background and Aim: Atopic dermatitis is a chronic inflammatory disease that is caused by an inflammatory process stimulated by Th2 cells. Acne vulgaris is a chronic inflammatory skin disease. It is associated with an increase in sebum secretion, unusual pilosebaceous keratinization and an increased inflammatory immune response. Propionibacterium acne can induce IL-17 production and Th1/Th17 response. The present study was designed to determine the prevalence of atopic dermatitis in patients with acne.</p>
<p>Methods: In this case-control study, the case group consisted of 75 individuals with acne and the control group consisted of 75 individuals without acne matched in age and gender. Both groups were interviewed for atopic dermatitis, asthma and allergic rhinitis symptoms in the past and present. </p>
<p>Results: Prevalence of atopic dermatitis at present in patients who had acne was significantly lower than those who did not have acne. There was no significant difference between case and control groups in frequency of atopic dermatitis in the past and frequency of asthma and allergic rhinitis in the present and past time.</p>
<p>Conclusion: The inverse relationship between prevalence of acne and atopic dermatitis can be related to activation of different immune responses (Th1 versus Th2), but more studies should be done to confirm this relationship.</p>
آکنه ولگاریس, درماتیت آتوپیک, پاتوژنز
acne vulgaris, atopic dermatitis, pathogenesis
75
80
http://jdc.tums.ac.ir/browse.php?a_code=A-10-1-265&slc_lang=fa&sid=1
Maryam
Ghiasi
مریم
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