fa بررسی ارتباط ملاسما با سندرم SAHA عمومى General پژوهشي Research <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:13.0pt"><span b="" mitra="" style="font-family:">زمینه و هدف:</span></span></b> <span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">ملاسما نوعی اختلال پیگمنتاسیون اکتسابی، مزمن و عودکننده می&shy;باشد که معمولأ نواحی پوستی در معرض نور آفتاب را بیشتر درگیر می‌کند. سندرم </span></span></span><span class="AbstractCharChar" new="" roman="" style="font-family:" times="">SAHA</span><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> نیز مخفف چهار کلمه سبوره، آکنه، هیرسوتیسم و آلوپسی آندروژنیک است. با توجه به همراهی ملاسما با برخی اجزای سندرم </span></span></span><span class="AbstractCharChar" new="" roman="" style="font-family:" times="">SAHA</span><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> مثل آکنه و هیرسوتیسم، این مطالعه جهت تعیین ارتباط ملاسما با سندرم </span></span></span><span class="AbstractCharChar" new="" roman="" style="font-family:" times="">SAHA</span><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> انجام شد.</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra""></span></span></span></span></span></span><br> <br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:13.0pt"><span b="" mitra="" style="font-family:">روش اجرا: </span></span></b><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">این مطالعه&shy; مورد ـ شاهدی بر روی 75 خانم دارای ملاسما به</span></span></span><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">‌</span></span></span><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">عنوان گروه مورد و 75 خانم بدون ملاسما به‌عنوان گروه شاهد انجام شد. اطلاعات در قالب پرسشنامه&shy;ای مشتمل بر 28 سؤال جمع</span></span></span><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">‌</span></span></span><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">آوری و تجزیه تحلیل شد.</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Mitra""></span></span></span></span></span></span><br> <br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:13.0pt"><span b="" mitra="" style="font-family:">یافته‌ها:</span></span></b> <span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">در گروه مورد 32 درصد مبتلا به هیرسوتیسم و 7/70 درصد مبتلا به آکنه بودند. در گروه شاهد 7/10 درصد مبتلا به هیرسوتیسم و 7/26 درصد مبتلا به آکنه بودند. ارتباط معناداری بین عوامل (سابقه ملاسما در بستگان درجه یک، سابقه&shy; هیرسوتیسم در بستگان درجه یک، آکنه، آلوپسی) و ابتلا به ملاسما وجود داشت. از بین گروه مورد، 3/5% مبتلا به سندرم </span></span></span><span class="AbstractCharChar" new="" roman="" style="font-family:" times="">SAHA</span><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> بودند.</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Mitra""></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:6.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:13.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br> <b><span dir="RTL" lang="AR-SA" style="font-size:13.0pt"><span b="" mitra="" style="font-family:">نتیجه‌گیری:</span></span></b> <span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">با توجه به اینکه اختلالات آندروژنیک در اتیولوژی سندرم </span></span></span><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span style="font-size:11.0pt">SAHA</span></span><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span dir="RTL" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> و ملاسما مطرح هستند به‌نظر می‌رسد ضایعات ملاسمایی در بیماران مبتلا به سندرم </span></span></span><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span style="font-size:11.0pt">SAHA</span></span><span class="AbstractCharChar" new="" roman="" style="font-family:" times=""><span dir="RTL" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> شایع‌تر است.</span></span></span> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:110%"><span style="tab-stops:1.0cm"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span bold="" new="" roman="" style="font-family:" times="">Background and Aim:</span></b> Melasma is an acquired, chronic, and recurrent pigmentation disorder that usually affects sun-exposed skin areas. SAHA syndrome is also an acronym for four words: seborrhea, acne, hirsutism, and androgenic alopecia. Given the association of melasma with some components of SAHA syndrome, such as acne and hirsutism, this study was conducted to determine the relationship between melasma and SAHA syndrome.<span dir="RTL" lang="AR-SA" style="font-size:13.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:110%"><span style="tab-stops:1.0cm"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span bold="" new="" roman="" style="font-family:" times="">Methods:</span></b> This case-control study was conducted on 75 women with melasma as the case group and 75 women without melasma as the control group. Data were collected in the form of a questionnaire consisting of 28 questions and analyzed.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:110%"><span style="tab-stops:1.0cm"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span bold="" new="" roman="" style="font-family:" times="">Results:</span></b> In the case group, 32% had hirsutism and 70.7% had acne. In the control group, 10.7% had hirsutism and 26.7% had acne. There was a significant association between factors (history of melasma in first-degree relatives, history of hirsutism in first-degree relatives, acne, alopecia) and melasma. Among the case group, 5.3% had SAHA syndrome.<span dir="RTL" lang="AR-SA" style="font-size:13.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span></span></span><br> <b><span style="font-size:11.0pt"><span bold="" new="" roman="" style="font-family:" times="">Conclusion:</span></span></b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""> Considering that androgenic disorders are implicated in the etiology of SAHA syndrome and melasma, it seems that melasma lesions are more common in patients with SAHA syndrome. </span></span> ملاسما, سندرم SAHA, آکنه, هیرسوتیسم melasma, saha syndrome, acne, hirsutism 245 252 http://jdc.tums.ac.ir/browse.php?a_code=A-10-1-380&slc_lang=fa&sid=1 Hasan Adalatkhah حسن عدالت‌خواه No Department of Dermatology, School of Medicine, Ardabil university of Medical Sciences, Ardabil, Iran گروه پوست، دانشکده پزشکی، دانشگاه علوم پزشکی اردبیل، اردبیل، ایران Shabnam Fahim شبنم فهیم shabnamfahim@gmail.com Yes Department of Dermatology, School of Medicine, Ardabil university of Medical Sciences, Ardabil, Iran گروه پوست، دانشکده پزشکی، دانشگاه علوم پزشکی اردبیل، اردبیل، ایران Sohrab Iranpour سهراب ایرانپور No Department of Community Medicine, School of Medicine, Ardabil university of Medical Sciences, Ardabil, Iran گروه پزشکی اجتماعی، دانشکده پزشکی، دانشگاه علوم پزشکی اردبیل، اردبیل، ایران Zahra Mohebbi زهرا محبی No School of Medicine, Ardabil university of Medical Sciences, Ardabil, Iran دانشکده پزشکی، دانشگاه علوم پزشکی اردبیل، اردبیل، ایران