Volume 5, Issue 2 (Volume 5, Number 2 2014)
jdc 2014, 5(2): 61-68 |
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Ahmad Nasrollahi S, Hassanzade H, Yazdanparast T, Marami Zenouz S, Mohiti Asli M, Firooz A. Safety assessment of 5 sunscreen products: Phase I controlled clinical trial. jdc 2014; 5 (2) :61-68
URL: http://jdc.tums.ac.ir/article-1-5070-en.html
URL: http://jdc.tums.ac.ir/article-1-5070-en.html
Saman Ahmad Nasrollahi * 
1, Hurnaz Hassanzade2 , Taraneh Yazdanparast2 , Shadi Marami Zenouz2 , Mehdi Mohiti Asli3 , Alireza Firooz2
1, Hurnaz Hassanzade2 , Taraneh Yazdanparast2 , Shadi Marami Zenouz2 , Mehdi Mohiti Asli3 , Alireza Firooz2
1- Center for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Sciences, Tehran, Iran , snasrollahi@tums.ac.ir
2- Center for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Sciences, Tehran, Iran
3- Aryan Kimia Tech Co., Tehran, Iran
2- Center for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Sciences, Tehran, Iran
3- Aryan Kimia Tech Co., Tehran, Iran
Abstract: (7090 Views)
Background and Aim: Sunscreens are an important part of photoprotection strategy. They are exposed to strict safety evaluation using human subjects such as in vivo studies of skin irritation. Biophysical parameters measurements could be used as fast and noninvasive methods to measure any destructive effect of cosmetic formulations on skin application sites.
Methods: Five sunscreens were selected from Iran's market to determine changes in Transepidermal Water Loss (TEWL), stratum corneum hydration, pH, melanin and hemoglobin contents by biometric assessments with MPA 580Cutometer®.
Results: There was no significant change in skin pH, melanin and hemoglobin contents before and after sunscreen application. Significant change in TEWL and stratum corneum hydration after use of some sunscreens might be contributed by the occlusive and humectant ingredients which used in base cream.
Conclusion: Application of the studied sunscreens on human volunteers has not shown any adverse effects and these formulations could be recommended to use.
Type of Study: Research |
Subject:
Special
Received: 2014/11/8 | Accepted: 2014/11/8 | Published: 2014/11/8
Received: 2014/11/8 | Accepted: 2014/11/8 | Published: 2014/11/8
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