Evaluation of provided clinical information on the histopathology request forms and histopathological findings to detect early mycosis fungoides according to ISCL algorithm

Nikoo, Azita; Hosseindoost, Babak; Khatami, Alireza

Volume 6, Issue 1 (Volume 6, Number 1 2015) jdc 2015, 6(1): 31-37 | Back to browse issues page

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Nikoo A, Hosseindoost B, Khatami A. Evaluation of provided clinical information on the histopathology request forms and histopathological findings to detect early mycosis fungoides according to ISCL algorithm. jdc 2015; 6 (1) :31-37
URL: http://jdc.tums.ac.ir/article-1-5109-en.html

Evaluation of provided clinical information on the histopathology request forms and histopathological findings to detect early mycosis fungoides according to ISCL algorithm

Azita Nikoo¹

, Babak Hosseindoost¹

, Alireza Khatami ^*

1- Department of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran , akhatami@tums.ac.ir

Abstract: (11594 Views)

Background and Aim: Mycosis fungoides (MF) is the most common primary cutaneous lymphoma. Diagnosis of early MF (eMF) is often difficult due to its resemblance of benign dermatoses. The aim of this study was to evaluate the role of provided clinical information on the histopathology request forms for diagnosis of eMF according to the International Society of Cutaneous Lympoma (ISCL) criteria. Methods: In this cross-sectional study, 108 patients admitted to Razi Hospital, Tehran, between April 2012 and November 2013, who were biopsied as eMF cases, were recruited. Based on partial application of ISCL algorithm, the checklist of clinical and histopathological findings were scored. Results: Eighty-five (78.7%) patients received maximum total clinical and histopathological scores (4) and their eMF were definitely diagnosed. Sixteen (14.8%) patients received a total score of 3, and suggestive eMF diagnosis was made. Further work up such as immunohistochemistry (IHC) evaluation were recommended. Seven patients (6.5%) received a total score of 2, which did not confirm eMF diagnosis. Follow up was recommended. In 14 (87.5%) of 16 patients who had received a total score of 3, the definite diagnosis of eMF was made according to the results of IHC. They were referred to receive treatment. In 2 patients (12.5%) diagnosis of eMF were not confirmed by IHC. They were recommended to undergo polymerase chain reaction (PCR) evaluation Conclusion: Many MF cases can be diagnosed in the early stages using a combination of clinical and histopathological criteria.

Keywords: mycosis fungoides, primary cutaneous lymphoma, diagnosis, diagnostic criteria

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Type of Study: Research | Subject: Special
Received: 2015/06/21 | Accepted: 2015/06/21 | Published: 2015/06/21