Comparison of cytokines IL10, IFN-Y, TNF-α, TGF-β and antioxidant enzymes glutathione reductase and glutathione peroxidase in saliva and serum of Iranian patients with alopecia totalis

Khaki, Leila; Vaezi, Gholamhasan; Ayatollahi, Azin; Firooz, alireza

Volume 11, Issue 3 (Volume 11, No 3 2020) jdc 2020, 11(3): 228-231 | Back to browse issues page

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Khaki L, Vaezi G, Ayatollahi A, Firooz A. Comparison of cytokines IL10, IFN-Y, TNF-α, TGF-β and antioxidant enzymes glutathione reductase and glutathione peroxidase in saliva and serum of Iranian patients with alopecia totalis. jdc 2020; 11 (3) :228-231
URL: http://jdc.tums.ac.ir/article-1-5480-en.html

Comparison of cytokines IL10, IFN-Y, TNF-α, TGF-β and antioxidant enzymes glutathione reductase and glutathione peroxidase in saliva and serum of Iranian patients with alopecia totalis

Leila Khaki¹

, Gholamhasan Vaezi¹

, Azin Ayatollahi ^*

², Alireza Firooz³

1- Department of Biology, Islamic Azad University, Damghan Branch, Damghan, Iran
2- Center for Research and Training in Skin Diseases and Leprosy,Tehran University of Medical Sciences, Tehran, Iran , azinay@gmail.com
3- Center for Research and Training in Skin Diseases and Leprosy,Tehran University of Medical Sciences, Tehran, Iran

Abstract: (1591 Views)

The aim of this study was to investigate the possibility of using saliva instead of serum (as a simpler method without the need for blood sampling) to determine the level of some cytokines and enzymes. In this study, the levels of cytokines IL10, IFN-Y, TNF-α, TGF-β and the antioxidant enzymes glutathione reductase and glutathione peroxidase were measured in the saliva and serum of three patients with alopecia totalis by ELISA. Comparison of the levels of these substances in saliva samples at 5 am, saliva at 11 am and serum at 11 am with Friedman test did not show a significant difference. Therefore, saliva samples may be a good alternative to serum in the study of immunological factors.

Keywords: cytokines, antioxidant enzymes, serum, saliva

Full-Text [PDF 1177 kb] (530 Downloads)

Type of Study: case report | Subject: Special
Received: 2020/12/29 | Accepted: 2020/10/31 | Published: 2020/10/31