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Full term newborns have a skin that rapidly develops towards adult skin. From the anatomical point of view, the differences are limited, but some changes at birth are responsible for the physiological differences between the skin of infants and adults. Newborns skin exhibits the same barrier function and absorption properties as adults, but external conditions for newborns may be different from those for adults, and these differences may lead to different skin absorption profiles between these two groups. Also, a baby's temperature regulation (transepidermal water loss (TEWL) and sweating) is not completely developed and the skin becomes easily infected, which is mainly due to changes in pH and immaturity of the skins defense system. This implies why only cosmetics with safe ingredients should be used for newborns. The initial aim is to formulate a simple, pure, gentle and pathogen-free product. Systemic side effects are not expected with washable products but should be taken into account for leave-on products. Great attention should be given to cosmetic products used in the napkin area, especially where there is a possibility of rash. If necessary, more safety precautions should be taken for these products.

Keywords: newborn, skin physiology, transepidermal water loss, formulation, diaper

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