Volume 15, Issue 1 (Volume 15, No 1 2024)
jdc 2024, 15(1): 14-30 |
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Ghiasi M, Pestehei S, Javadi S, Seyhoun S. The use of adult stem cells in the treatment of skin diseases. jdc 2024; 15 (1) :14-30
URL: http://jdc.tums.ac.ir/article-1-5708-en.html
URL: http://jdc.tums.ac.ir/article-1-5708-en.html
1- Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran , mahdieh.ghiasi@yahoo.com
2- Department of Anesthesiology, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Science, Tehran, Iran
3- Department of Neurosurgery, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Science, Tehran, Iran
4- Department of Tissue Engineering and Applied Cellular Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Science, Tehran, Iran / Transplantation Products Research Center and Bank, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Anesthesiology, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Science, Tehran, Iran
3- Department of Neurosurgery, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Science, Tehran, Iran
4- Department of Tissue Engineering and Applied Cellular Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Science, Tehran, Iran / Transplantation Products Research Center and Bank, Tehran University of Medical Sciences, Tehran, Iran
Abstract: (531 Views)
The skin, as the outer layer, protects the body against external factors. Wounds can negatively affect its performance. Wound healing includes three stages of inflammation, proliferation, and regeneration, which begin immediately after injury. Also, some factors such as infection, obesity and diabetes can disrupt the natural healing process that leads to chronic wounds. Various surgical and non-surgical treatments have been used to manage chronic wounds, including hyperbaric oxygen therapy, ultrasound therapy, laser therapy, and skin grafting. These treatments have advantages and disadvantages. Recently, stem cells have been used as a surgical treatment for chronic wound healing. Stem cells are highly proliferative cells that can maintain their ability to divide and regenerate for a long time. Among the different types of stem cells, MSCs have many advantages such as ease of harvest, availability, and multilineage differentiation capacity for cell therapy. In addition, they showed some properties that could be useful in the clinical application of ASCs, including angiogenesis, immune system modulation, and improved tissue regeneration. This study was conducted by collecting data from reliable scientific sources from April 1401 to January 1402 at the Research Institute of Neurosciences, Brain and Spinal Cord Injury Research Center of Tehran University of Medical Sciences. Several studies have shown that ASCs can be a suitable candidate for wound healing due to their special characteristics. The purpose of this review is to discuss the use of ASCs in wound repair and healing as a new strategy in the treatment of skin problems.
Type of Study: Review |
Subject:
General
Received: 2024/07/3 | Accepted: 2024/05/4 | Published: 2024/05/4
Received: 2024/07/3 | Accepted: 2024/05/4 | Published: 2024/05/4
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