Volume 16, Issue 1 (Volume 16, No 1 2025)
jdc 2025, 16(1): 35-49 |
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Roshanbakht F, Hassanzadeh Nemati N, Attaran Kakhki N. Therapeutic potential of narasin and silica nanocomposites against skin pathogens: a review. jdc 2025; 16 (1) :35-49
URL: http://jdc.tums.ac.ir/article-1-5778-en.html
URL: http://jdc.tums.ac.ir/article-1-5778-en.html
1- Department of Biomedical Engineering, Faculty of Applied Medical Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran
2- Department of Biomedical Engineering, Faculty of Applied Medical Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran ,hasanzadeh@srbiau.ac.ir
3- Department of Medical Nanotechnology, Faculty of Applied Medical Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran
2- Department of Biomedical Engineering, Faculty of Applied Medical Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran ,
3- Department of Medical Nanotechnology, Faculty of Applied Medical Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran
Abstract: (1044 Views)
Skin infections caused by pathogenic bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa have become a serious challenge in the field of antibacterial therapies, especially in the context of antibiotic resistance. In this regard, the simultaneous use of classical antibiotic combinations with advanced nanostructures is considered a novel and effective approach. Narasin, an ionophore antibiotic of natural origin, has a high potential in inhibiting bacterial growth due to its ability to disrupt cell membrane function and ion transport. On the other hand, silica nanostructures, especially mesoporous silica nanoparticles, play an important role in enhancing antibacterial activity due to their properties such as biocompatibility, drug loading capability, controlled release, and production of reactive oxygen species.
Recent studies have shown that the combination of narasin with silica nanostructures enhances the synergistic antibacterial effects, increases drug stability, and improves penetration into bacterial biofilms. This combination has also been effective in reducing the dosage and systemic toxicity. Despite promising results in laboratory and animal models, challenges such as the assessment of cytotoxicity, precise release control, and the need for extensive clinical studies remain.
In this article, while comprehensively reviewing the properties and functions of narasin and silica nanostructures, the mechanisms of their combined effects on skin pathogenic bacteria are discussed and future prospects in the development of nanobiotechnological therapies are reviewed.
Recent studies have shown that the combination of narasin with silica nanostructures enhances the synergistic antibacterial effects, increases drug stability, and improves penetration into bacterial biofilms. This combination has also been effective in reducing the dosage and systemic toxicity. Despite promising results in laboratory and animal models, challenges such as the assessment of cytotoxicity, precise release control, and the need for extensive clinical studies remain.
In this article, while comprehensively reviewing the properties and functions of narasin and silica nanostructures, the mechanisms of their combined effects on skin pathogenic bacteria are discussed and future prospects in the development of nanobiotechnological therapies are reviewed.
Keywords: narasin, mesoporous silica nanoparticles, skin infections, antibacterial agents, drug delivery systems
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