Volume 16, Issue 2 (Volume 16, No 2 2025)
jdc 2025, 16(2): 105-113 |
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Yazdani Hamid F. The impact of isotretinoin on thyroid function and autoimmunity: a review of clinical studies. jdc 2025; 16 (2) :105-113
URL: http://jdc.tums.ac.ir/article-1-5795-en.html
URL: http://jdc.tums.ac.ir/article-1-5795-en.html
Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran , f.yhamidi@gmail.com
Abstract: (929 Views)
This article reviews the impact of isotretinoin on thyroid function, based on various clinical studies. Isotretinoin, a commonly prescribed treatment for severe acne, has been linked to significant changes in thyroid hormone levels, including elevated TSH and decreased FT3 and FT4. Several studies suggest that long-term isotretinoin use can induce thyroid dysfunction, with potential effects on thyroid volume, hormone levels, and the immune system. Autoimmune thyroid conditions, particularly autoimmune hypothyroidism, have also been observed in patients receiving isotretinoin. These findings highlight the need for regular thyroid monitoring during isotretinoin therapy, especially for patients with autoimmune predispositions. Additionally, the article emphasizes the importance of collaboration between endocrinologists and dermatologists to ensure optimal patient care. Further studies are needed to elucidate the mechanisms behind these changes and their clinical significance.
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