Volume 16, Issue 2 (Volume 16, No 2 2025)                   jdc 2025, 16(2): 123-129 | Back to browse issues page

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Mohamadi F, Zahedi K. A review of novel treatments and diagnostic challenges in Erosive Lichen Planus of the genitalia. jdc 2025; 16 (2) :123-129
URL: http://jdc.tums.ac.ir/article-1-5797-en.html
1- Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran , lord66farid@gmail.com
2- Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (853 Views)
Erosive lichen planus of the genitalia is a chronic inflammatory autoimmune disease primarily affecting the genital mucosa, causing pain, discomfort, and impairing urinary, reproductive, and sexual functions. This condition is more common in postmenopausal women and is often associated with other autoimmune diseases such as vitiligo and thyroid disorders. Standard treatments include topical and systemic corticosteroids, but several challenges persist, especially in cases resistant to conventional therapies. This review discusses novel and alternative treatment options, including immunomodulators and systemic therapies like tacrolimus, secukinumab, and anti-malarial drugs. It also emphasizes the importance of personalized treatment strategies for patients resistant to standard treatments. Additionally, the psychological impacts of the disease on patients’ quality of life and the need for a multidimensional approach in managing these patients are highlighted.
 
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Type of Study: Review | Subject: General

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