Volume 16, Issue 3 (Volume 16, No 3 2025)
jdc 2025, 16(3): 157-168 |
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Kazemi M, Khatibi F, Nasr S, Shirkavand A, Ataie Fashtami L. Importance of photodynamic therapy and inactivation in wounds and tissue repair: a review. jdc 2025; 16 (3) :157-168
URL: http://jdc.tums.ac.ir/article-1-5809-en.html
URL: http://jdc.tums.ac.ir/article-1-5809-en.html
1- Department of Pathogenic Microorganisms, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran
2- Department of Photodynamic, Medical Laser Research Center (MLRC), Yara Institute, ACECR, Tehran, Iran
3- Department of Pathogenic Microorganisms, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran * Department of Photodynamic, Medical Laser Research Center (MLRC), Yara Institute, ACECR, Tehran, Iran
4- Department of Pathogenic Microorganisms, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran * National Center for Genetic and Biological Resources of Iran, ACECR, Tehran, Iran ,shirkavand@acecr.ac.ir
5- Department of Regenerative Medicine, Stem Cell Institute, Royan Institute, Tehran, Iran
2- Department of Photodynamic, Medical Laser Research Center (MLRC), Yara Institute, ACECR, Tehran, Iran
3- Department of Pathogenic Microorganisms, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran * Department of Photodynamic, Medical Laser Research Center (MLRC), Yara Institute, ACECR, Tehran, Iran
4- Department of Pathogenic Microorganisms, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran * National Center for Genetic and Biological Resources of Iran, ACECR, Tehran, Iran ,
5- Department of Regenerative Medicine, Stem Cell Institute, Royan Institute, Tehran, Iran
Abstract: (472 Views)
Antimicrobial photodynamic inactivation is emerging as a non‑antibiotic strategy for treating infected wounds, particularly those harboring multidrug‑resistant bacteria. aPDI relies on a photosensitizer that, when illuminated with an appropriate wavelength, generates reactive oxygen species (ROS) that cause rapid, non‑specific damage to microbial membranes, proteins and nucleic acids. Effective photosensitizers combine high quantum yield to penetrate both Gram‑positive and Gram‑negative organisms, while light sources such as LEDs or lasers provide precise control of irradiance and tissue penetration. Clinical investigations have demonstrated that aPDI, alone or in combination with low‑dose antibiotics or growth factors, can reduce bacterial load in chronic wounds by up to 84 % and accelerate healing. Current challenges include limited light penetration, optimal dosing, and potential phototoxicity, emerging solutions involve nanocarrier‑delivered photosensitizers, oxygen‑releasing dressings, and ultrasound‑mediated activation to enhance efficacy and safety.
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