Volume 14, Issue 4 (Volume 14, No 4 2024)
jdc 2024, 14(4): 189-198 |
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Samadi A, Nassiri Kashani M, Ayatollahi A, Moosavi Z, Ahmdian Yazdi H, Firooz A. Clinical safety and efficacy assessment of 5 Iranian hyaluronic acid-based dermal fillers for improvement of moderate to severe nasolabial folds. jdc 2024; 14 (4) :189-198
URL: http://jdc.tums.ac.ir/article-1-5698-en.html
URL: http://jdc.tums.ac.ir/article-1-5698-en.html
Aniseh Samadi1 
, Mansour Nassiri Kashani1 , Azin Ayatollahi1 , Zahrabeigom Moosavi1 , Hasti Ahmdian Yazdi1 , Alireza Firooz * 2
, Mansour Nassiri Kashani1 , Azin Ayatollahi1 , Zahrabeigom Moosavi1 , Hasti Ahmdian Yazdi1 , Alireza Firooz * 2
1- Clinical Evaluation Laboratory of Pharmaceutical, Cosmetic and Health Products, Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
2- Clinical Evaluation Laboratory of Pharmaceutical, Cosmetic and Health Products, Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran ,firozali@tums.ac.ir
2- Clinical Evaluation Laboratory of Pharmaceutical, Cosmetic and Health Products, Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract: (416 Views)
Background and Aim: Recently, many Iranian companies have started manufacturing hyaluronic acid based dermal fillers. Current review aimed to assess and compare the clinical safety and efficacy of 5 Iranian hyaluronic acid based dermal fillers.
Methods: The first part of the study reported, the overall safety and efficacy of 5 Iranian hyaluronic acid based dermal fillers for improvement of nasolabial folds in 150 participants (age 44.30±9.97 years) using clinical and objectives assessment methods. In the second part, we performed a comparative study among 5 tested dermal fillers.
Results: Generally, at weeks 2, 12, and 24, 80.6%, 63.3%, and 60.66% of the participants, showed one grade or more improvement in the severity of nasolabial folds respectively. In all visits, the nasolabial folds biophysical parameters as well as the echo density dermis improved significantly compared to baseline. In comparative study, two fillers with the hyaluronic acid concentration of 24 mg/ml, showed the best objective efficacy, while in clinical evaluations, the filler containing mannitol has the best performance in reducing the severity of nasolabial folds showed.
Conclusion: Iranian hyaluronic acid based dermal fillers showed different levels of safety and efficacy for improvement of moderate to severe nasolabial folds, with efficacy.
Methods: The first part of the study reported, the overall safety and efficacy of 5 Iranian hyaluronic acid based dermal fillers for improvement of nasolabial folds in 150 participants (age 44.30±9.97 years) using clinical and objectives assessment methods. In the second part, we performed a comparative study among 5 tested dermal fillers.
Results: Generally, at weeks 2, 12, and 24, 80.6%, 63.3%, and 60.66% of the participants, showed one grade or more improvement in the severity of nasolabial folds respectively. In all visits, the nasolabial folds biophysical parameters as well as the echo density dermis improved significantly compared to baseline. In comparative study, two fillers with the hyaluronic acid concentration of 24 mg/ml, showed the best objective efficacy, while in clinical evaluations, the filler containing mannitol has the best performance in reducing the severity of nasolabial folds showed.
Conclusion: Iranian hyaluronic acid based dermal fillers showed different levels of safety and efficacy for improvement of moderate to severe nasolabial folds, with efficacy.
Type of Study: Research |
Subject:
General
Received: 2024/04/14 | Accepted: 2024/02/4 | Published: 2024/02/4
Received: 2024/04/14 | Accepted: 2024/02/4 | Published: 2024/02/4
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