Volume 15, Issue 4 (Volume 15, No 4 2025)
jdc 2025, 15(4): 269-275 |
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Hatefi Minaei H, Khamesipour A, Firooz A, Miraminmohammadi A, Eskandari S, Mirazizi S et al . Pilot study of efficacy of injection of interferon-gamma (IFN-γ) on skin lesions caused by leishmania major in Balb /C mice. jdc 2025; 15 (4) :269-275
URL: http://jdc.tums.ac.ir/article-1-5760-en.html
URL: http://jdc.tums.ac.ir/article-1-5760-en.html
Homa Hatefi Minaei1 
, Ali Khamesipour * 2, Alireza Firooz3 , Akram Miraminmohammadi3 , Seyedebrahim Eskandari3 , Shahla Mirazizi1 , Minoo Tasbihi3
, Ali Khamesipour * 2, Alireza Firooz3 , Akram Miraminmohammadi3 , Seyedebrahim Eskandari3 , Shahla Mirazizi1 , Minoo Tasbihi3
1- Dorsa Daroo Pharmaceutical Company, Tehran, Iran
2- Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran ,ali.khamesipour@gmail.com
3- Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
2- Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran ,
3- Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
Abstract: (59 Views)
Background and Aim: Leishmaniasis is difficult to control and is not cost-effective in endemic areas. Antimony toxic compounds is the drug of choice, which drug resistance is increasing. Animal studies showed that interferon-gamma deficiency impairs the recovery of leishmaniasis. In this study, the therapeutic effects of subcutaneous injection of recombinant gamma interferon on leishmaniasis lesions in Balb/ C mice were evaluated.
Methods: 40 Balb/ C mice were infected with Leishmania major. After developing lesions, the therapeutic effects of interferon gamma alone or in combination with glucantime were investigated. Also, the standard treatment of glucantime and the control group without treatment were evaluated for comparison.
Results: The treatment groups (glucantime, gamma interferon, and gamma interferon-glucantime) had a significant difference (P<0.01) in terms of reduction in the footpad thickness compared to the control group. There was no significant difference in the mortality rate in the groups receiving gamma interferon and the group receiving standard glucantime treatment.
Conclusion: It seems that gamma interferon was effective in treating cutaneous leishmaniasis lesions in Balb/c mice alone and in combination with standard treatment and can be considered as an alternative treatment.
Methods: 40 Balb/ C mice were infected with Leishmania major. After developing lesions, the therapeutic effects of interferon gamma alone or in combination with glucantime were investigated. Also, the standard treatment of glucantime and the control group without treatment were evaluated for comparison.
Results: The treatment groups (glucantime, gamma interferon, and gamma interferon-glucantime) had a significant difference (P<0.01) in terms of reduction in the footpad thickness compared to the control group. There was no significant difference in the mortality rate in the groups receiving gamma interferon and the group receiving standard glucantime treatment.
Conclusion: It seems that gamma interferon was effective in treating cutaneous leishmaniasis lesions in Balb/c mice alone and in combination with standard treatment and can be considered as an alternative treatment.
Type of Study: Research |
Subject:
General
Received: 2025/04/4 | Accepted: 2026/02/4 | Published: 2026/02/4
Received: 2025/04/4 | Accepted: 2026/02/4 | Published: 2026/02/4
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